The Effect of 8 Weeks Aerobic Training and Vitamin C on Creatine Kinase of Serum Levels in Type 2 Diabetes Patients

Objective: Diabetes mellitus is a metabolic disorder associated with impaired serum skeletal muscle pain enzymes levels. The purpose of this study was to investigate the effect of 8 weeks aerobic training with and without vitamin C consumption on serum levels of Creatine Kinase (CK) in type 2 diabetic patients (T2DM). Materials and Methods: In this clinical trial 45 women (30-45 years) with T2DM were randomly assigned into one of these 3 groups: aerobic training (3 sessions a week for 45 minutes), aerobic training with 250 mg/day vitamin C supplementation and control (without exercise and vitamin C). Fasting serum levels of CK were measured before and 24 hours after the last exercise session. The results were analyzed using descriptive and inferential statistics (analysis of variance, LSD post hoc test, dependent T test for hypothesis testing) by SPSS19 software. Results: Aerobic training as well as aerobic training plus vitamin C reduced significantly concentrations of CK compared to the control (P-value= 0.037, P-value= 0.017) respectively. However, There were no significant differences in CK levels between intervention groups (P-value= 0.899). Conclusion: This study showed that aerobic exercise with or without vitamin C supplementation is effective in reducing CK levels in T2DM. So, in order to reduce at least one of the markers of muscle damage (CK), aerobic exercises are recommended in T2DM, in the absence of contraindications.